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Trogdor (100w CO2 Laser) Checklist

Turn on machine: large switch, right side of cabinet
Confirm blower is running: ducting will obviously be moving air
Turn on computer: if it isn't already
Wait ~10s before opening Lightburn: a background process needs to configure the laser first
Open Lightburn, wait for homing cycle: the machine will automatically “home” itself i.e. confirm the position of each axis by driving motors to reach endstop sensors

Pick a coordinate system: you probably want to use absolute coordinates. See the official docs
Cut selected graphics (or not): sometimes it's helpful to enable “cut selected graphics” in Lightburn, sometimes not. Best to double check if it's enabled before a surprise either way.
Focus laser to workpiece: use the move tab in Lightburn with the plastic focusing puck or macros from the console tab to jog to the right height for common material thicknesses
Test power/speed: Pick some starting values by cutting a material test pattern or referencing one from the small box on top of the machine.
Align design to workpiece: make sure everything fits as expected in x/y axes using Lightburn's frame button

Send it: Run your job in Lightburn
Don't go far!: You need to keep an eye on the laser during the entire job. When lasers catch things on fire, they tend to do so quickly.

Wait ~5 minutes: Make sure the chiller has had time to cool down the tube, and the blower has fully evacuated any remaining fumes
Turn off machine: large switch, right side of cabinet