Turn on machine: large switch, right side of cabinet

Confirm blower is running: ducting will obviously be moving air

Turn on computer: if it isn't already

Wait ~10s before opening Lightburn: a background process needs to configure the laser first

Open Lightburn, wait for homing cycle: the machine will automatically “home” itself i.e. confirm the position of each axis by driving motors to reach endstop sensors

Pick a coordinate system: you probably want to use absolute coordinates. See the official docs

Cut selected graphics (or not): sometimes it's helpful to enable “cut selected graphics” in Lightburn, sometimes not. Best to double check if it's enabled before a surprise either way.

Focus laser to workpiece: use the move tab in Lightburn with the plastic focusing puck or macros from the console tab to jog to the right height for common material thicknesses

Align design to workpiece: make sure everything fits as expected in x/y axes using Lightburn's frame button